DBH*444G/A polymorphism of the dopamine-β-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms

@article{Khnke2005DBH444GAPO,
  title={DBH*444G/A polymorphism of the dopamine-β-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms},
  author={Michael D. K{\"o}hnke and Werner Kolb and Annette M K{\"o}hnke and Ulrich Lutz and Sandra Schick and Anil Batra},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={113},
  pages={869-876}
}
As the enzyme dopamine-β-hydroxylase (DβH) converts dopamine to norepinephrine and both transmitters seem to be involved in the pathology of alcoholism and severe alcohol withdrawal symptoms, the gene encoding DβH (DBH) was applied to explore the genetic background of alcoholism and severe withdrawal symptoms. 102 healthy control subjects and 208 alcoholics, including 97 patients with a history of mild withdrawal symptoms, 57 with a history of alcohol withdrawal seizure (AWS) and 82 with a… CONTINUE READING

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