DBG2OLC: Efficient Assembly of Large Genomes Using Long Erroneous Reads of the Third Generation Sequencing Technologies

@inproceedings{Ye2016DBG2OLCEA,
  title={DBG2OLC: Efficient Assembly of Large Genomes Using Long Erroneous Reads of the Third Generation Sequencing Technologies},
  author={Chengxi Ye and Christopher Michael Hill and Shigang Wu and Jue Ruan and Zhanshan Ma},
  booktitle={Scientific reports},
  year={2016}
}
The highly anticipated transition from next generation sequencing (NGS) to third generation sequencing (3GS) has been difficult primarily due to high error rates and excessive sequencing cost. The high error rates make the assembly of long erroneous reads of large genomes challenging because existing software solutions are often overwhelmed by error correction tasks. Here we report a hybrid assembly approach that simultaneously utilizes NGS and 3GS data to address both issues. We gain… CONTINUE READING
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