DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.

@article{Butler1997DBA1ME,
  title={DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.},
  author={Debra M. Butler and A M Malfait and Lesley J Mason and P J Warden and George Kollias and Ravinder N. Maini and Marc Feldmann and Fionula Mary Brennan},
  journal={Journal of immunology},
  year={1997},
  volume={159 6},
  pages={2867-76}
}
Arthritis spontaneously develops in mice expressing a human TNF-alpha transgene modified with the 3' untranslated region of beta-globin. We have backcrossed these mice onto the arthritis-susceptible DBA/1 background and found an acceleration of the onset of arthritis with successive generations of interbreeding. Bioactive TNF-alpha in primary synovial membrane cell cultures was significantly higher in the DBA/1 transgenic mice than in transgenic mice on the original background. Elevated levels… CONTINUE READING