DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics

  title={DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics},
  author={Li Liu and Jing Lei and Stephan J. Sanders and A. Jeremy Willsey and Yan Kou and A. Ercument Cicek and Lambertus L. Klei and Cong Lu and Xin He and Mingfeng Li and Rebecca A. Muhle and Avi Ma’ayan and James P Noonan and Nenad Sestan and Kathryn A McFadden and Matthew W. State and Joseph D. Buxbaum and Bernie J Devlin and Kathryn Roeder},
  booktitle={Molecular autism},
BACKGROUND De novo loss-of-function (dnLoF) mutations are found twofold more often in autism spectrum disorder (ASD) probands than their unaffected siblings. Multiple independent dnLoF mutations in the same gene implicate the gene in risk and hence provide a systematic, albeit arduous, path forward for ASD genetics. It is likely that using additional non-genetic data will enhance the ability to identify ASD genes. METHODS To accelerate the search for ASD genes, we developed a novel algorithm… CONTINUE READING
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