DATATOP: A decade of neuroprotective inquiry

@article{Shoulson1998DATATOPAD,
  title={DATATOP: A decade of neuroprotective inquiry},
  author={Ira Shoulson},
  journal={Annals of Neurology},
  year={1998},
  volume={44}
}
  • I. Shoulson
  • Published 1 September 1998
  • Psychology
  • Annals of Neurology
In 1987, the DATATOP clinical trial was initiated to examine the benefits of deprenyl (selegiline) and α‐tocopherol in slowing the progression of Parkinson's disease (PD). After 14 ± 6 (mean ± SD) months of controlled observation, deprenyl 10 mg/day was found to significantly delay the time until enough disability developed to warrant the initiation of levodopa therapy. This effect was largely sustained during the overall 8.2 years of observation, including open‐label deprenyl treatment and a… 

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