DATATOP: A decade of neuroprotective inquiry

  title={DATATOP: A decade of neuroprotective inquiry},
  author={I. Shoulson},
  journal={Annals of Neurology},
In 1987, the DATATOP clinical trial was initiated to examine the benefits of deprenyl (selegiline) and α‐tocopherol in slowing the progression of Parkinson's disease (PD). After 14 ± 6 (mean ± SD) months of controlled observation, deprenyl 10 mg/day was found to significantly delay the time until enough disability developed to warrant the initiation of levodopa therapy. This effect was largely sustained during the overall 8.2 years of observation, including open‐label deprenyl treatment and a… Expand
Impact of sustained deprenyl (selegiline) in levodopa‐treated Parkinson's disease: A randomized placebo‐controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial
Levodopa‐treated Parkinson's disease patients who had been treated with deprenyl for up to 7 years, compared with patients who were changed to a placebo after about 5 years, experienced slower motor decline and were more likely to develop dyskinesias but less likely to developed freezing of gait. Expand
Clinical neuroprotection in Parkinson's disease — Still waiting for the breakthrough
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A double-blind, placebo-controlled randomized clinical trial of α-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis
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The Fabulous Neuroprotection of Selegiline: Memoir and Prospectus
  • W. Landau
  • Psychology, Medicine
  • Journal of child neurology
  • 2010
The thrust of my critique was not that protective function was disproved, but rather that it was not proved; the unexpected discovery from consistent clinical evaluations that deprenyl directly improved the symptoms of parkinsonism. Expand
High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study
Neither the primary nor the secondary outcome measures could determine whether a megadose of vitamin E is efficacious in slowing disease progression in ALS as an add-on therapy to riluzol. Expand
Neuroprotection in Parkinson's disease.
  • A. Schapira
  • Medicine, Biology
  • Parkinsonism & related disorders
  • 2009
A major focus in Parkinson's disease research is to produce drugs or other interventions that can slow or stop clinical progression and so target dopaminergic and non-dopaminergic pathways, and it is logical to assume that the best chance of developing such therapies will be based on forming a better understanding of the aetiology and pathogenesis of PD. Expand
Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin‐induced nigrostriatal dopaminergic degeneration
Compared with selegiline, rasagiline is more potent in protecting neurodegeneration induced by UPS impairment and may, therefore, exert disease‐modifying effects in PD. Expand
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Design of clinical trials of gene therapy in Parkinson disease
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