DAT isn’t all that: cocaine reward and reinforcement requires Toll Like Receptor 4 signaling

@inproceedings{Northcutt2015DATIA,
  title={DAT isn’t all that: cocaine reward and reinforcement requires Toll Like Receptor 4 signaling},
  author={Alexis L Northcutt and Mark R Hutchinson and Xiang Wang and Michael V Baratta and Takato Hiranita and Tyler A. Cochran and Matthew B Pomrenze and Erika L Galer and Theresa A. Kopajtic and C M Li and Jos{\'e} Amat and Gloria Larson and Donald C. Cooper and Yong Huang and Casey E O'Neill and Hang Yin and Nancy R. Zahniser and Jonathan Katz and Kenner C. Rice and Steven F. Maier and Ryan K. Bachtell and Linda R. Watkins},
  booktitle={Molecular Psychiatry},
  year={2015}
}
The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to their ability to activate the mesolimbic dopamine system. Resulting increases in extracellular dopamine in the nucleus accumbens (NAc) are traditionally thought to result from cocaine’s ability to block dopamine transporters (DATs). Here we demonstrate that cocaine also interacts with the immunosurveillance receptor complex, Toll-like receptor 4 (TLR4), on microglial cells to initiate central innate… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Similar Papers

Loading similar papers…