DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia.

@article{Hkansson2004DARPP32AM,
  title={DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia.},
  author={Kerstin H{\aa}kansson and Maria Lindskog and Laura Pozzi and Alessandro Usiello and Gilberto Fisone},
  journal={Parkinsonism & related disorders},
  year={2004},
  volume={10 5},
  pages={281-6}
}
The dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) is abundantly expressed in the medium spiny neurons of the striatum. Phosphorylation catalysed by cAMP-dependent protein kinase (PKA) converts DARPP-32 into an inhibitor of protein phosphatase-1. In contrast, phosphorylation catalysed by cyclin dependent kinase-5 on Thr75 converts DARPP-32 into an inhibitor of PKA. Changes in the state of phosphorylation of DARPP-32 reinforce the behavioral effects produced by stimulation or… CONTINUE READING
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