DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

@article{Hemmings1984DARPP32AD,
  title={DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1},
  author={Hugh C Hemmings and Paul Greengard and H. Y. Lim Tung and Philip S. Cohen},
  journal={Nature},
  year={1984},
  volume={310},
  pages={503-505}
}
The neurotransmitter dopamine has been demonstrated by biochemical1, histochemical2 and immunocytochemical3,4 techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a regional distribution in the mammalian brain very similar to that of dopamine-containing nerve terminals, being highly concentrated in the basal ganglia5–8. The state of… CONTINUE READING
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