DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.

Abstract

Genetic factors play an important role in the etiology of late-onset Alzheimer's disease (LOAD). We tested gene-centric single nucleotide polymorphisms (SNPs) on chromosome 9 and identified two SNPs in the death-associated protein kinase, DAPK1, that show significant association with LOAD. SNP rs4878104 was significantly associated with LOAD in our… (More)

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@article{Li2006DAPK1VA, title={DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.}, author={Yonghong Li and Andrew Grupe and Charles Rowland and P. Nowotny and John S. K. Kauwe and Scott Smemo and Anthony L. Hinrichs and Kristina M. Tacey and Timothy A Toombs and Shirley S Kwok and Joseph J. Catanese and T. White and Taylor J. Maxwell and Paul Hollingworth and Richard Sesin Abraham and David C Rubinsztein and Carol Brayne and Fabienne Wavrant-De Vri{\`e}ze and John Hardy and Michael O'Donovan and Simon Lovestone and John C. Morris and Leon Thal and Michael Owen and Julie Williams and Alison M. Goate}, journal={Human molecular genetics}, year={2006}, volume={15 17}, pages={2560-8} }