DAP5 ameliorates cisplatin-induced apoptosis of renal tubular cells.

@article{Gao2012DAP5AC,
  title={DAP5 ameliorates cisplatin-induced apoptosis of renal tubular cells.},
  author={Jian-jun Gao and Guang-yan Cai and Yi-chun Ning and Lin Wei Liu and Ju-rong Yang and Dan Dong and Bo Fu and Yang Lu and Shao-yuan Cui and Xiangmei Chen},
  journal={American journal of nephrology},
  year={2012},
  volume={35 5},
  pages={456-65}
}
BACKGROUND Nephrotoxicity of cisplatin limits its clinical application. Cisplatin-induced acute renal tubular epithelial cell apoptosis is one of the major mechanisms of cisplatin nephrotoxicity. Here, the role and regulation of death-associated protein 5 (DAP5) in cisplatin-induced tubular cell apoptosis were investigated. METHODS After upregulation of DAP5 expression by plasmid transfection and downregulation of DAP5 expression by small interfering RNA in human kidney tubular epithelial… CONTINUE READING

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