DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.

@article{Spahn2015DAP12EI,
  title={DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.},
  author={Jessica Helen Spahn and Wenjun Li and Alejandro Cano Bribriesco and Jie Liu and Hua Shen and Aida Ibricevic and J Z Pan and Bernd H Zinselmeyer and Steven L. Brody and Daniel R Goldstein and Alexander S Krupnick and Andrew E. Gelman and Mark J Miller and Daniel Kreisel},
  journal={Journal of immunology},
  year={2015},
  volume={194 8},
  pages={4039-48}
}
Neutrophils are critical mediators of innate immune responses and contribute to tissue injury. However, immune pathways that regulate neutrophil recruitment to injured tissues during noninfectious inflammation remain poorly understood. DAP12 is a cell membrane-associated protein that is expressed in myeloid cells and can either augment or dampen innate inflammatory responses during infections. To elucidate the role of DAP12 in pulmonary ischemia/reperfusion injury (IRI), we took advantage of a… CONTINUE READING