DAMPs ramp up drug toxicity.

  title={DAMPs ramp up drug toxicity.},
  author={Jacquelyn J. Maher},
  journal={The Journal of clinical investigation},
  volume={119 2},
The clinical syndrome of acetaminophen-induced liver injury represents the combined result of drug toxicity and a potent innate immune response that follows drug-induced cell death. In this issue of the JCI, Imaeda and colleagues report that DNA released from dying hepatocytes is a key stimulus of innate immune activation in the acetaminophen-treated mouse liver (see the related article beginning on page 305). They present evidence indicating that hepatocyte DNA promotes immune activation by… CONTINUE READING
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