DAMPs as mediators of sterile inflammation in aging-related pathologies

  title={DAMPs as mediators of sterile inflammation in aging-related pathologies},
  author={N. Fel'dman and Aviva Rotter-Maskowitz and E. Okun},
  journal={Ageing Research Reviews},
  • N. Fel'dman, Aviva Rotter-Maskowitz, E. Okun
  • Published 2015
  • Biology, Medicine
  • Ageing Research Reviews
  • Accumulating evidence indicates that aging is associated with a chronic low-level inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free inflammation caused by mechanical trauma, ischemia, stress or environmental conditions such as ultra-violet radiation. These damage-related stimuli induce the secretion of molecular agents collectively termed danger-associated molecular patterns (DAMPs). DAMPs are recognized by virtue of specialized innate immune receptors… CONTINUE READING
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