DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.

@article{Onogi1995DAMGOAM,
  title={DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.},
  author={Tatsuhiro Onogi and Masaru Minami and Yoshikazu Katao and Takeshi Nakagawa and Yoshimasa Aoki and Takashi Toya and Seishi Katsumata and Mitsutoshi Satoh},
  journal={FEBS letters},
  year={1995},
  volume={357 1},
  pages={
          93-7
        }
}
The structural basis of mu-opioid receptor (OPR) for the specificity in its ligand binding was investigated using chimeric mu/delta-OPRs. Replacement of the region around the first extracellular loop of delta-OPR with the corresponding region of mu-OPR gave the resultant chimeric receptor the similar affinity to DAMGO compared with the native mu-OPR. The reciprocal replacement deprived the high affinity to DAMGO from mu-OPR. These results indicate that the difference(s) in the structure around… CONTINUE READING

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