DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells.

@article{Montell2001DAGAF,
  title={DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells.},
  author={Eul{\'a}lia Montell and Marco Turini and Mario Marotta and Michael Roberts and V{\'e}ronique No{\'e} and Carlos Ciudad and Katherine Mac{\'e} and Anna Maria G{\'o}mez-Foix},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={280 2},
  pages={E229-37}
}
The increased availability of saturated lipids has been correlated with development of insulin resistance, although the basis for this impairment is not defined. This work examined the interaction of saturated and unsaturated fatty acids (FA) with insulin stimulation of glucose uptake and its relation to the FA incorporation into different lipid pools in cultured human muscle. It is shown that basal or insulin-stimulated 2-deoxyglucose uptake was unaltered in cells preincubated with oleate… CONTINUE READING
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