DAG Lipase Activity Is Necessary for TRP Channel Regulation in Drosophila Photoreceptors

@article{Leung2008DAGLA,
  title={DAG Lipase Activity Is Necessary for TRP Channel Regulation in Drosophila Photoreceptors},
  author={Hung-Tat Leung and Julie Tseng-Crank and Eunju Kim and Cecon T Mahapatra and Shikoh Shino and Ying Zhou and Lingling An and Rebecca W. Doerge and William L. Pak},
  journal={Neuron},
  year={2008},
  volume={58},
  pages={884-896}
}
In Drosophila, a phospholipase C-mediated signaling cascade links photoexcitation of rhodopsin to the opening of the TRP/TRPL channels. A lipid product of the cascade, diacylglycerol (DAG) and its metabolite(s), polyunsaturated fatty acids (PUFAs), have both been proposed as potential excitatory messengers. A crucial enzyme in the understanding of this process is likely to be DAG lipase (DAGL). However, DAGLs that might fulfill this role have not been previously identified in any organism. In… CONTINUE READING
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