DAG Lipase Activity Is Necessary for TRP Channel Regulation in Drosophila Photoreceptors

  title={DAG Lipase Activity Is Necessary for TRP Channel Regulation in Drosophila Photoreceptors},
  author={Hung-Tat Leung and Julie Tseng-Crank and Eunju Kim and Cecon T Mahapatra and Shikoh Shino and Ying Zhou and Lingling An and Rebecca W. Doerge and William L. Pak},
In Drosophila, a phospholipase C-mediated signaling cascade links photoexcitation of rhodopsin to the opening of the TRP/TRPL channels. A lipid product of the cascade, diacylglycerol (DAG) and its metabolite(s), polyunsaturated fatty acids (PUFAs), have both been proposed as potential excitatory messengers. A crucial enzyme in the understanding of this process is likely to be DAG lipase (DAGL). However, DAGLs that might fulfill this role have not been previously identified in any organism. In… CONTINUE READING
44 Citations
25 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 44 extracted citations


Publications referenced by this paper.
Showing 1-10 of 25 references

a 2008 Elsevier Inc . of the first sn 1DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

  • B. T. Bloomquist, R. D. Shortridge, +5 authors W. L. Pak
  • J . Cell Biol .
  • 2008

Phototransduction in Drosophila: Use of microarrays in cloning genes identified by chemically induced mutations causing ERG defects

  • Leung, H.-T, +8 authors W. L. Pak
  • In Signal Transduction in the Retina,
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…