DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.

@article{Narbonne2015DAF18PTENLA,
  title={DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.},
  author={Patrick Narbonne and Paul S Maddox and Jean-Claude Labb{\'e}},
  journal={Development},
  year={2015},
  volume={142 24},
  pages={4230-41}
}
During development, stem cell populations rapidly proliferate to populate the expanding tissues and organs. During this phase, nutrient status, by systemically affecting insulin/IGF-1 signalling, largely dictates stem cell proliferation rates. In adults, however, differentiated stem cell progeny requirements are generally reduced and vary according to the spatiotemporal needs of each tissue. We demonstrate here that differential regulation of germline stem cell proliferation rates in… CONTINUE READING
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