DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.

@article{Yu2014DACT2IF,
  title={DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.},
  author={Yuanzi Yu and Wenji Yan and Xuefeng Liu and Yun Feng Jia and Baoping Cao and Yingyan Yu and Youyong Lv and Malcolm Vernon Brock and Jame G Herman and Julien D.F Licchesi and Yunsheng Yang and Ming qing Guo},
  journal={American journal of cancer research},
  year={2014},
  volume={4 6},
  pages={
          710-24
        }
}
Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is a key regulator of Wnt signaling pathway. The purpose of this study is to explore the epigenetic changes and the function ofDACT2 in human gastric cancer (GC). Eight human gastric cancer cell lines, 167 cases of primary gastric cancer and 8 cases of normal gastric mucosa were involved in this study. In addition, methylation Specific PCR (MSP), semi-quantitative RT-PCR, colony formation assay, flow cytometry assay, siRNA… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Identification and characterization of human DAPPER1 and DAPPER2 genes in silico

M. Katoh
  • Int J Oncol
  • 2003
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Nature meets nurture: molecular ge- DACT2 is a Wnt signaling inhibitor in gastric cancer

AN Milne, F Carneiro, C O’Morain, GJ. Offerhaus
  • Am J Cancer Res
  • 2014
VIEW 1 EXCERPT

Genetic Aspects of Gastric Cancer Instability

  • TheScientificWorldJournal
  • 2012
VIEW 1 EXCERPT