DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis.

@article{Chang2017DACH1SS,
  title={DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis.},
  author={Andrew H Chang and Brian C Raftrey and Gaetano D'amato and Vinay N. Surya and Aruna Poduri and Heidi I. Chen and Andrew Goldstone and Joseph Y. Woo and Gerald Gendall Fuller and Alexander R Dunn and Kristy Red-Horse},
  journal={Genes & development},
  year={2017},
  volume={31 13},
  pages={
          1308-1324
        }
}
Sufficient blood flow to tissues relies on arterial blood vessels, but the mechanisms regulating their development are poorly understood. Many arteries, including coronary arteries of the heart, form through remodeling of an immature vascular plexus in a process triggered and shaped by blood flow. However, little is known about how cues from fluid shear stress are translated into responses that pattern artery development. Here, we show that mice lacking endothelial Dach1 had small coronary… CONTINUE READING
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