DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1.

@article{Lee2012DACH1RC,
  title={DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1.},
  author={Jae-Woong Lee and Hyeng-Soo Kim and Seonggon Kim and Junmo Hwang and Young Hun Kim and Ga Young Lim and Wern-Joo Sohn and Suk-Ran Yoon and Jae-Young Kim and Tae Sung Park and Kwon Moo Park and Zae Young Ryoo and Sanggyu Lee},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={420 1},
  pages={91-5}
}
The cell-fate determination factor Dachshund, a component of the Retinal Determination Gene Network (RDGN), has a role in breast tumor proliferation through the repression of cyclin D1 and several key regulators of embryonic stem cell function, such as Nanog and Sox2. However, little is known about the role of DACH1 in a myeloid lineage as a cell cycle regulator. Here, we identified the differential expression levels of extensive cell cycle regulators controlled by DACH1 in myeloid progenitor… CONTINUE READING
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