DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.

@article{Wu2003DACH1IT,
  title={DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.},
  author={Kongming Wu and Ying Yang and Chenguang Wang and Maria Antonietta Davoli and Mark W D'Amico and Anping Li and Kveta Cveklov{\'a} and Zbyněk Kozm{\'i}k and Michael Phillip Lisanti and R. Graham G. Russell and Ales Cvekl and Richard G. Pestell},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 51},
  pages={51673-84}
}
The vertebrate homologues of Drosophila dachsund, DACH1 and DACH2, have been implicated as important regulatory genes in development. DACH1 plays a role in retinal and pituitary precursor cell proliferation and DACH2 plays a specific role in myogenesis. DACH proteins contain a domain (DS domain) that is conserved with the proto-oncogenes Ski and Sno. Since the Ski/Sno proto-oncogenes repress AP-1 and SMAD signaling, we hypothesized that DACH1 might play a similar cellular function. Herein… CONTINUE READING