DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing.

@article{Hoe2006DAB1AR,
  title={DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing.},
  author={Hyang-Sook Hoe and Tracy S. Tran and Yasuji Matsuoka and Brian W Howell and George William Rebeck},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 46},
  pages={35176-85}
}
Numerous cytoplasmic adaptor proteins, including JIP1, FE65, and X11alpha, affect amyloid precursor protein (APP) processing and Abeta production. Dab1 is another adaptor protein that interacts with APP as well as with members of the apoE receptor family. We examined the effect of Dab1 on APP and apoEr2 processing in transfected cells and primary neurons. Dab1 interacted with APP and apoEr2 and increased levels of their secreted extracellular domains and their cytoplasmic C-terminal fragments… CONTINUE READING
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