DAAM Is Required for Thin Filament Formation and Sarcomerogenesis during Muscle Development in Drosophila

@inproceedings{Molnr2014DAAMIR,
  title={DAAM Is Required for Thin Filament Formation and Sarcomerogenesis during Muscle Development in Drosophila},
  author={Imre Moln{\'a}r and Ede Migh and Szil{\'a}rd Szikora and Tibor Kalm{\'a}r and Attila G V{\'e}gh and Ferenc De{\'a}k and Szilvia Bark{\'o} and Be{\'a}ta Bugyi and Zacharias Orfanos and J{\'a}nos Kov{\'a}cs and G{\'a}bor Juh{\'a}sz and G. Varo and Mikl{\'o}s Nyitrai and John Sparrow and J{\'o}zsef Mih{\'a}ly},
  booktitle={PLoS genetics},
  year={2014}
}
During muscle development, myosin and actin containing filaments assemble into the highly organized sarcomeric structure critical for muscle function. Although sarcomerogenesis clearly involves the de novo formation of actin filaments, this process remained poorly understood. Here we show that mouse and Drosophila members of the DAAM formin family are sarcomere-associated actin assembly factors enriched at the Z-disc and M-band. Analysis of dDAAM mutants revealed a pivotal role in… CONTINUE READING
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