DA-9201 shows anti-asthmatic effects by suppressing NF-кB expression in an ovalbumin-lnduced mouse model of asthma

  title={DA-9201 shows anti-asthmatic effects by suppressing NF-кB expression in an ovalbumin-lnduced mouse model of asthma},
  author={Seung-Ho Lee and Mi Jung Seo and Seul Min Choi and Yong Sung Sohn and Kyung Koo Kang and Byoung Ok Ahn and Jong W. Kwon and Moohi Yoo},
  journal={Archives of Pharmacal Research},
Nuclear factor kappa (NF-кB) regulates the expression of multiple cytokines, chemokines, and cell adhesion molecules that are involved in the pathogenesis of asthma. We investigated the anti-asthmatic effects and the mechanism of action of DA-9201, an extract of the black rice, in a mouse model of asthma. Mice immunized with ovalbumin (OVA) were administered with DA-9201 (30, 100 or 300 mg/kg) or dexamethasone (DEXA, 3 mg/kg) for 2 weeks and challenged with aerosolized OVA during the last 3… 

Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor.

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Inhibitors of transcription factor nuclear factor-kappa beta (NF-κβ)-DNA binding

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Oryza sa synth



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Current understanding of the pathophysiologic mechanisms by which Th2 cytokines induce airway disease, and the factors that predispose to the generation of these pathogenic cells in response to inhalation of ubiquitous aero-allergens are discussed.

Inhaled corticosteroids: current products and their role in patient care.

  • E. Bleecker
  • Biology, Medicine
    The Journal of allergy and clinical immunology
  • 1998

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