DA-9201 shows anti-asthmatic effects by suppressing NF-кB expression in an ovalbumin-lnduced mouse model of asthma

@article{Lee2005DA9201SA,
  title={DA-9201 shows anti-asthmatic effects by suppressing NF-кB expression in an ovalbumin-lnduced mouse model of asthma},
  author={Seung-Ho Lee and Mi Jung Seo and Seul Min Choi and Yong Sung Sohn and Kyung Koo Kang and Byoung Ok Ahn and Jong W. Kwon and Moohi Yoo},
  journal={Archives of Pharmacal Research},
  year={2005},
  volume={28},
  pages={1350-1357}
}
Nuclear factor kappa (NF-кB) regulates the expression of multiple cytokines, chemokines, and cell adhesion molecules that are involved in the pathogenesis of asthma. We investigated the anti-asthmatic effects and the mechanism of action of DA-9201, an extract of the black rice, in a mouse model of asthma. Mice immunized with ovalbumin (OVA) were administered with DA-9201 (30, 100 or 300 mg/kg) or dexamethasone (DEXA, 3 mg/kg) for 2 weeks and challenged with aerosolized OVA during the last 3… 

Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor.

TLDR
The results suggest that BLT2 plays a pivotal, mediatory role in the pathogenesis of asthma, acting through a "reactive oxygen species-NF-kappaB"-linked inflammatory signaling pathway.

Inhibitors of transcription factor nuclear factor-kappa beta (NF-κβ)-DNA binding

The mammalian transcription factor nuclear factor-kappa beta (NF-κβ) is an ubiquitous transcription factor responsible for the regulation of over 150 genes, impacting virtually every aspect of

Bronchoalveolar Lavage Fluid microRNA-146a: A Biomarker of Disease Severity and Pulmonary Function in Patients With Silicosis

TLDR
MiR-146a was significantly associated with the disease severity and pulmonary function of silicosis and was also associated with decreased pulmonary function measures, pulmonary function impairment, and restrictive ventilator dysfunction.

Oryza sa synth

References

SHOWING 1-10 OF 31 REFERENCES

Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation

TLDR
A crucial role is demonstrated in vivo in the expression of important molecules that have been implicated in the pathogenesis of asthma by mice deficient in the p50 subunit of nuclear factor (NF)- κB.

The role of T lymphocytes in the pathogenesis of asthma.

TLDR
The efficacy of cyclosporin A and anti-CD4 treatment in patients with chronic severe asthma argues for continued T-cell involvement, but whether remodeling contributes to pathology inaccessible to anti-inflammatory treatment or T- cell immunotherapy will be an important future question.

Immunologic basis of antigen-induced airway hyperresponsiveness.

TLDR
Current understanding of the pathophysiologic mechanisms by which Th2 cytokines induce airway disease, and the factors that predispose to the generation of these pathogenic cells in response to inhalation of ubiquitous aero-allergens are discussed.

Inhaled corticosteroids: current products and their role in patient care.

  • E. Bleecker
  • Biology, Medicine
    The Journal of allergy and clinical immunology
  • 1998

Activation and localization of transcription factor, nuclear factor-kappaB, in asthma.

TLDR
Airway cells from patients with asthma show increased activation of NF-kappaB, which may be the basis for increased expression of many inflammatory genes and for the perpetuation of chronic airway inflammation in asthma.

Correlation between nuclear factor-kappaB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma.

TLDR
The results demonstrate that the kinetics of NF-kappaB activity is strongly related to the course of the disease and confirm the relevance ofNF-kappB as a putative target in asthma therapy and uncommon p65 homodimers could transactivate, in BCs, a subset of genes, such as ICAM-1, characteristic of chronic airway inflammation.

Phenotypic characterization of T lymphocytes emigrating into lung tissue and the airway lumen after antigen inhalation in sensitized mice.

TLDR
The OA-dependent, temporally regulated emigration of T cells into the bronchial lumen after exposure to aerosolized antigen may be correlated with the accumulation of cells that express the memory phenotype with enhanced expression of adhesion molecules.

Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation.

TLDR
It is now believed that airway inflammation leads to AHR, airway remodeling, and mucus hyperplasia, and it is clear that persistent inflammation is central to the pathogenesis of asthma.

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it

The evaluation of antianaphylactic effect of Oryza sativa L. in rats.

TLDR
Results indicate that Os-DJ possess antianaphylactic activity by inhibition of histamine release from mast cells in vivo and in vitro.