D600 as a direct blocker of Ca-dependent K currents in Helix neurons.

@article{Gola1985D600AA,
  title={D600 as a direct blocker of Ca-dependent K currents in Helix neurons.},
  author={Maurice Gola and C. Ducreux},
  journal={European journal of pharmacology},
  year={1985},
  volume={117 3},
  pages={311-22}
}
The effects of D600 and inorganic Ca blockers on calcium and Ca-dependent potassium currents were investigated in Helix neurons under current and voltage-clamp conditions. At low concentrations (10-50 microM), D600 enlarged the Ca-dependent spike in U cells, which was blocked at higher concentrations. D600 130 and 17 microM reduced the Ca current ICa and the Ca-dependent K current IK(Ca) respectively by half. IK(Ca) blockade developed rapidly and was almost irreversible. ICa blockade had a… CONTINUE READING