D3 dopamine receptors are down-regulated in amphetamine sensitized rats and their putative antagonists modulate the locomotor sensitization to amphetamine

@article{Chiang2003D3DR,
  title={D3 dopamine receptors are down-regulated in amphetamine sensitized rats and their putative antagonists modulate the locomotor sensitization to amphetamine},
  author={Yao-Chang Chiang and Pei-Chun Chen and Jin-Chung Chen},
  journal={Brain Research},
  year={2003},
  volume={972},
  pages={159-167}
}
A functional role for the dopamine D3 receptor in the induction and expression of behavioural sensitization to ethanol in mice
TLDR
Results suggest a modulatory role for the D3R in behavioural sensitization to EtOH, where D2R blockade is associated with induction of EtOH sensitization and D4R stimulation is associatedwith expression of Etoh sensitization.
A selective D3 receptor antagonist YQA14 attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice
TLDR
Brain D3 receptors are critically involved in the reward and psychomotor-stimulating effects of METH, and YQA14 deserves further study as a potential medication for METH addiction.
Role of dopamine D1‐like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
TLDR
It is suggested that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1‐like receptors to influence the acquisition of methamphetamine‐induced behavioral sensitization, traits that may influence continued methamphetamine use.
Differential susceptibility to ethanol and amphetamine sensitization in dopamine D3 receptor-deficient mice
TLDR
A necessary role for the D3R in EtOH but not AMPH sensitization is suggested, possibly through postreceptor intracellular mechanisms and results suggest that different neurochemical mechanisms underlie sensitization to different drugs of abuse.
Dopamine D3 receptor antisense oligodeoxynucleotide potentiates imipramine-induced dopaminergic behavioural supersensitivity
TLDR
The present results suggest that increased dopamine D3 receptor expression following antidepressant treatments is not involved in the mechanism of dopaminergic supersensitivity, and are consistent with evidence supporting an inhibitory role for dopamine D 3 receptors in motor activity, both in normal and in sensitized subjects.
Examination of the role of dopamine D3 receptors in behavioural sensitization to ethanol.
TLDR
D1/D3R interactions in sensitized and control mice are investigated and whether EtOH sensitization leads to changes in D3R binding using [I]-7-OH-PIPAT autoradiography is examined.
Sex differences in nicotine sensitization and conditioned hyperactivity in adolescent rats neonatally treated with quinpirole: role of D2 and D3 receptor subtypes.
TLDR
In males, D priming enhanced sensitization to nicotine and produced conditioned hyperactivity, which were blocked by eticlopride and nafadotride, and these results have implications for psychosis and comorbidity of nicotine abuse in adolescence.
Chronic d-amphetamine depresses an imaging marker of arachidonic acid metabolism in rat brain.
TLDR
The ability of chronic d-Amph after 1-d washout to down-regulate baseline values of k* probably reflects neuroplastic changes in brain AA signalling, and may correspond to depressive behaviours noted following withdrawal from chronic amphetamine in humans and in rats.
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References

SHOWING 1-10 OF 47 REFERENCES
Repeated intravenous cocaine administration: Locomotor activity and dopamine D2/D3 receptors
TLDR
The D3 receptors in the Striatal and nucleus accumbens D3 receptor involvement in the expression of cocaine‐induced behavioral sensitization may be differentially involved in the locomotor stimulation and reinforcing aspects of repeated cocaine administration.
Differential development of autoreceptor subsensitivity and enhanced dopamine release during amphetamine sensitization.
TLDR
It is suggested that autoreceptor subsensitivity is a transient effect which may be related to the development of sensitization, whereas enhancement of amphetamine-stimulated dopamine release does not accompany early stages of behavioral sensitized, but may be involved in the persistence of the phenomenon after longer withdrawal periods.
Adaptive Increase in D3 Dopamine Receptors in the Brain Reward Circuits of Human Cocaine Fatalities
TLDR
The elevated number of [3H]-(+)-7-OH-DPAT binding sites demonstrates that adaptive changes in the D3 receptor in the reward circuitry of the brain are associated with chronic cocaine abuse, and suggests that the D 3 receptor may be a useful target for drug development of anti-cocaine medications.
Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens.
TLDR
Iontophoretic application of selective D1 (SKF 38393) and D2 (quinpirole) DA receptor agonists was utilized to determine the extent to which each of these DA receptor subtypes is altered by repeated cocaine administration.
Evidence for selective involvement of dopamine D1 receptors of the ventral tegmental area in the behavioral sensitization induced by intra-ventral tegmental area injections of D-amphetamine.
TLDR
The results reported here confirm that repeated intra-VTA AMPH injections induce behavioral sensitization, as revealed by the potentiation of the locomotor response to peripheral challenges with AMPH 4 or 15 days after treatment.
Central administration of dopamine D3 receptor antisense to rat: effects on locomotion, dopamine release and [3H]spiperone binding
TLDR
It is concluded that the antisense strategy is useful for investigating the functional role of dopamine D3 receptors and that the dopamine D 3 receptor is involved in rat locomotor behaviour.
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