D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons.

@article{Davila2003D3DA,
  title={D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons.},
  author={Viviana Davila and Zhen Yan and Liviu C Craciun and D. Logothetis and David Sulzer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 13},
  pages={5693-7}
}
Substantia nigra (SN) dopamine neurons express D2 and D3 dopamine autoreceptors. A physiological role for the D3 receptor has not been identified, but an activation of G-protein-gated inwardly rectifying potassium (GIRK; also known as Kir3) channels is strongly implicated because D3 receptors activate channels composed of GIRK2 subunits in cell lines. We confirmed that acutely dissociated SN dopamine neurons indeed contain D3 and GIRK2 subunit mRNA using single-cell RT-PCR. We then tested… CONTINUE READING
22 Citations
22 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Dopamine D3 receptors expressed by all mesencephalic dopamine neurons

  • J Diaz, C Pilon, +4 authors P Sokoloff
  • J Neurosci
  • 2000
2 Excerpts

Similar Papers

Loading similar papers…