D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

@inproceedings{Lin2015D2HGDHRA,
  title={D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2},
  author={Ai-fu Lin and Saman Abbas and Sung Tae KimS.T. Kim and Manoela Marques Ortega and Hakim Bouamar and Yissela Escobedo and Prakash Varadarajan and Yuejuan Qin and Jessica A. Sudderth and Eduard Schulz and Alexander J A Deutsch and Sumitra Mohan and Peter Ulz and Peter Neumeister and Dinesh Rakheja and Xiaoli Gao and Andrew P Hinck and Susan T Weintraub and Ralph J DeBerardinis and Heinz Sill and Patricia L M Dahia and Ricardo Aguiar},
  booktitle={Nature communications},
  year={2015}
}
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG to D2-hydroxyglutarate (D2-HG) disrupting α-KG-dependent dioxygenases. However, the physiological relevance of controlling the interconversion of D2-HG into α-KG, mediated by D2-hydroxyglutarate dehydrogenase (D2HGDH), remains obscure. Here we show that wild-type D2HGDH elevates α-KG levels, influencing histone and DNA methylation, and HIF1α hydroxylation. Conversely, the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…