D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex.

@article{Li2011D2RO,
  title={D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex.},
  author={Y C Li and Christoph Kellendonk and Eleanor H Simpson and Eric R Kandel and Wen-Jun Gao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 29},
  pages={12107-12}
}
Two distinct defects are thought to be important for the pathophysiology of schizophrenia. One is an increase of D2 receptors (D2Rs) in the striatum and another is a decrease in the GABAergic function in the prefrontal cortex (PFC). Whether these two defects are functionally linked is not known. We previously reported that selective overexpression of D2Rs in the striatum of the mouse causes behavioral abnormality associated with PFC functions. Using patch-clamp recording, we find that… CONTINUE READING