D2 dopamine receptor gene and cigarette smoking: a reward gene?

@article{Noble1994D2DR,
  title={D2 dopamine receptor gene and cigarette smoking: a reward gene?},
  author={Ernest Pascal Noble and Sachiko T St Jeor and Terry Ritchie and Karl Syndulko and Stephen C. St. Jeor and Robert J. Fitch and Robert L. Brunner and RobertS. Sparkes},
  journal={Medical hypotheses},
  year={1994},
  volume={42 4},
  pages={
          257-60
        }
}
There is now growing evidence that the less prevalent allele (A1) of the D2 dopamine receptor (DRD2) gene is strongly associated with severe alcoholism. Similarly, subjects who abuse illegal drugs or who are obese also show a significantly higher prevalence of the A1 DRD2 allele compared to controls. Moreover, cigarette smokers, both past and current, demonstrate significantly higher prevalence of the A1 allele than nonsmokers. In as much as alcohol, cocaine, opiates, nicotine and food are… CONTINUE READING
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