D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele.

@article{Thompson1997D2DR,
  title={D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele.},
  author={Jill Maria Thompson and Nagheme J Thomas and Andrew A Singleton and Margaret A Piggott and Stephanie E. Lloyd and Elaine K. Perry and Christopher M Morris and Robert H. Perry and I. Nicol Ferrier and Jenny A Court},
  journal={Pharmacogenetics},
  year={1997},
  volume={7 6},
  pages={479-84}
}
The relationship between a dopamine D2 receptor genetic polymorphism at the Taq1 A locus and the level of D2 receptor binding was investigated in normal, middle aged to elderly subjects with no psychiatric or neurological disorders. D2 receptor binding was measured by autoradiography in the caudate, putamen and nucleus accumbens, using the specific D2 receptor ligand [3H]-raclopride. In a sample of 44 individuals, only one was homozygous for the A1 allele, 25 were homozygous for A2 and 18 were… CONTINUE READING
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