D2 and 5HT2A receptor occupancy of different doses of quetiapine in schizophrenia: a PET study

@article{Gefvert2001D2A5,
  title={D2 and 5HT2A receptor occupancy of different doses of quetiapine in schizophrenia: a PET study},
  author={Ola Gefvert and Tommie Lundberg and I-M. Wieselgren and Mats Bergstr{\"o}m and Bengt L{\aa}ngstr{\"o}m and Frits-axel Wiesel and Leif H. Lindstr{\"o}m},
  journal={European Neuropsychopharmacology},
  year={2001},
  volume={11},
  pages={105-110}
}
OBJECTIVE Quetiapine is a novel antipsychotic agent with many atypical features, including low D(2) and higher 5HT(2A) affinity in vitro, low propensity to induce extra-pyramidal side effects and minimal effects on prolactin levels. The purpose of this study was to investigate, using positron emission tomography (PET), the relationship between plasma concentrations of different doses of quetiapine and occupancy of D(2) and 5HT(2A) receptors in schizophrenic patients. METHODS Five patients… Expand
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