D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia

  title={D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia},
  author={M. Buchsbaum and B. Christian and D. Lehrer and T. Narayanan and J. Mukherjee},
  journal={Schizophrenia Research},
  • M. Buchsbaum, B. Christian, +2 authors J. Mukherjee
  • Published 2006
  • Psychology, Medicine
  • Schizophrenia Research
  • BACKGROUND Abnormalities in the dopaminergic system are implicated in schizophrenia. [F-18]fallypride is a highly selective, high affinity PET ligand well suited for measuring D2/D3 receptor availability in the extrastriatal regions of the brain including thalamus, prefrontal, cingulate, and temporal cortex, brain regions implicated in schizophrenia with other imaging modalities. METHODS Resting [F-18]fallypride PET studies were acquired together with anatomical MRI for accurate… CONTINUE READING
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