D1 receptors modulate glutamate transmission in the ventral tegmental area.

Abstract

Perfusion of the D1 agonist, SKF-82958, through a microdialysis probe implanted in the ventral tegmental area produced a dose-dependent increase in extracellular glutamate and GABA. The increase in extracellular glutamate occurred at approximately 30x lower dose than the elevation in GABA. The increase in extracellular glutamate by SKF-82958 was blocked by… (More)

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@article{Kalivas1995D1RM, title={D1 receptors modulate glutamate transmission in the ventral tegmental area.}, author={Peter W. Kalivas and Patricia Duffy}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={1995}, volume={15 7 Pt 2}, pages={5379-88} }