D1-receptor drugs and cocaine-seeking behavior: investigation of receptor mediation and behavioral disruption in rats

@article{Alleweireldt2002D1receptorDA,
  title={D1-receptor drugs and cocaine-seeking behavior: investigation of receptor mediation and behavioral disruption in rats},
  author={Andrea T. Alleweireldt and Kenneth Ferris Kirschner and Camille Bond Blake and Janet L. Neisewander},
  journal={Psychopharmacology},
  year={2002},
  volume={168},
  pages={109-117}
}
Dopamine D1-receptor antagonists and agonists both attenuate cocaine-seeking behavior (i.e., operant responding in the absence of cocaine reinforcement) elicited by a cocaine prime or cocaine-paired stimuli. It remains unclear whether these effects are D1-receptor mediated. The present study tested whether a D1 antagonist (SCH-23390) would reverse the attenuating effects of a D1 agonist (SKF-81297) on cocaine-seeking behavior and whether behavioral disruption is involved in these effects. Rats… CONTINUE READING