D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality.

@article{CoppaHopman2009D1RA,
  title={D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality.},
  author={Rd Coppa-Hopman and Jan Galle and D Pimkine},
  journal={Journal of psychopharmacology},
  year={2009},
  volume={23 6},
  pages={672-85}
}
The objective of the following experiment was to induce a pathogenic hypofrontal condition by administering a dopamine-1 receptor (D(1)R) antagonist to rats. The pathophysiological effect of this manipulation upon glutamate-based long-term potentiation (LTP) in the medial prefrontal cortex (mPFC) was examined in vivo. Subjects were surgically implanted with… CONTINUE READING