D1 dopamine receptor: A putative neurochemical and behavioral link to cocaine action

  title={D1 dopamine receptor: A putative neurochemical and behavioral link to cocaine action},
  author={Michele Hummel and Ellen M. Unterwald},
  journal={Journal of Cellular Physiology},
Cocaine is one of the most abused psychostimulants known to man and as such, researchers have been steadfast in their attempts to understand the neurobiological mechanisms responsible for its abuse. Cocaine undoubtedly wreaks havoc on a number of mammalian neuronal neurotransmitter systems, and it is maintained that this dysregulatory effect supports cocaine abuse. Cocaine's mechanism of action has been well described. Cocaine binds differentially to the dopamine, serotonin, and norepinephrine… 
Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolescent Mice Frontal Cortex
It is suggested that GABA uptake naturally decreases during mice development from preadolescence until adulthood and that dopamine (DA) D 1 -like receptors are key players in the regulation of GABA uptake levels following a single COC exposure in adolescent mice.
Receptor-mediated mechanisms for drugs of abuse and brain development
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  • Biology
    Receptors in the Evolution and Development of the Brain
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The Lack of A2A Adenosine Receptors Diminishes the Reinforcing Efficacy of Cocaine
It is demonstrated that A2A adenosine receptors play an important role in cocaine addictive properties, and these receptors seem to be required to develop the addictive effects of this drug.
A Single In Vivo Exposure to Cocaine Abolishes Endocannabinoid-Mediated Long-Term Depression in the Nucleus Accumbens
It is reported that a single in vivo cocaine administration abolishes eCB-LTD and cocaine-induced loss of eCB retrograde signaling is caused by a reduction in the ability of mGluR5 to translate anterograde glutamate transmission into retrograde eCB signaling.
Selective Antagonism at Dopamine D3 Receptors Prevents Nicotine-Triggered Relapse to Nicotine-Seeking Behavior
The results suggest that DA D3 receptors are involved in the reinstatement of nicotine-seeking behavior independently of any interaction with the primary reinforcing effects of nicotine itself, and point toward the potential use of selective D3 receptor antagonists for the pharmacotherapeutic management of relapse to drug-seeking behaviors.
Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine
Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?
The focus is on recent evidence from laboratory animal models (and some evidence in humans) implicating these receptors in the acute and chronic effects of numerous abused drugs, as well as in the control of drug seeking and taking.
Dopamine D1 receptor, but not dopamine D2 receptor, is a critical regulator for acute cocaine-enhanced gene expression
It is suggested that dopamine D1 receptor, but not dopamine D2 receptor, plays a critical role in regulating acute cocaine-enhanced gene expression in the striatum, and ERK1/2 pathway may contribute to this regulation.


Neurobiology of cocaine abuse.
Cocaine receptors on dopamine transporters are related to self-administration of cocaine.
It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum, but not with theirPotencies in binding to a large number of other presynaptic and postsynaptic binding sites.
Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens.
Iontophoretic application of selective D1 (SKF 38393) and D2 (quinpirole) DA receptor agonists was utilized to determine the extent to which each of these DA receptor subtypes is altered by repeated cocaine administration.
Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration.
Recordings from NAc neurons in cocaine-treated rats indicated that these cells were supersensitive to the inhibitory effects of iontophoretic DA, which could lead to greatly enhanced DA transmission and may help to explain some aspects of cocaine-induced behavioral sensitization.
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
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The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a
The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys.
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  • Biology, Psychology
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The finding that selective D1 receptor agonists can function as positive reinforcers implicates D1 receptors in the reinforcing effects of psychomotor stimulants and of other drugs that stimulate D1 antagonists.
Effects of dopamine receptor antagonists (D1 and D2) on the demand for smoked cocaine base in rhesus monkeys
These data suggest that both dopamine receptor antagonists reduce the reinforcing effectiveness of smoked cocaine base, and they have a greater effect on cocaine consumption at higher FR values.