D1-Receptor-related priming is attenuated by antisense-meditated 'knockdown' of fosB expression.

@article{Crocker1998D1ReceptorrelatedPI,
  title={D1-Receptor-related priming is attenuated by antisense-meditated 'knockdown' of fosB expression.},
  author={Stephen J Crocker and Maurizio Morelli and N. Wigle and Yusaku Nakabeppu and George S. Robertson},
  journal={Brain research. Molecular brain research},
  year={1998},
  volume={53 1-2},
  pages={
          69-77
        }
}
Administration of dopamine receptor agonists to rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway produce changes in the denervated striatum that enable a subsequent injection to elicit more vigorous circling. The molecular basis for this behavioural phenomenon, termed priming, is unknown. D1-receptor-related priming has been associated with a profound elevation of immediate-early gene (IEG) expression in the denervated striatum. Since immediate-early genes encode… CONTINUE READING

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