D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent.

@article{Li2014DserineinducedIO,
  title={D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent.},
  author={Xia Li and Yuan-yuan Zhang and Zhao-qin Chen and Zheng-Lin Jiang and Li Sun and Lihua Xu and Yao Ming Yang and Yun-Feng Zhang},
  journal={CNS neuroscience & therapeutics},
  year={2014},
  volume={20 11},
  pages={951-60}
}
AIMS Our previous studies indicate that glycine can inhibit N-methyl-D-aspartate receptor (NMDAR) responses induced by high concentrations of NMDA in rat hippocampal neurons. The present study was designed to observe whether D-serine induces inactivation of NMDARs in cultured rat hippocampal neurons and to investigate the underlying mechanisms of this… CONTINUE READING