D-psicose, an epimer of D-fructose, favorably alters lipid metabolism in Sprague-Dawley rats.

@article{Nagata2015DpsicoseAE,
  title={D-psicose, an epimer of D-fructose, favorably alters lipid metabolism in Sprague-Dawley rats.},
  author={Yasuo Nagata and Akane Kanasaki and Shizuka Tamaru and Kazunari Tanaka},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 12},
  pages={
          3168-76
        }
}
D-Psicose, a C3 epimer of D-fructose, is known to lower body weight and adipose tissue weight and affect lipid metabolism. The precise mechanism remains unknown. It has been reported that D-psicose has a short half-life and is not metabolized in the body. To determine how D-psicose modifies lipid metabolism, rats were fed diets with or without 3% D-psicose for 4 weeks. Rats were decapitated without fasting every 6 h over a period of 24 h. Changes in serum and liver lipid levels, liver enzyme… Expand
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References

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Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats.
TLDR
The results suggest that a supplement of D-psicose in the diet suppresses hepatic lipogenic enzyme activities, and the lower abdominal fat accumulation in rats fed a D-PSicose diet might result from lower lipogenesis in the liver. Expand
D-psicose is a rare sugar that provides no energy to growing rats.
TLDR
D-psicose is a rare sugar providing zero energy that may be useful in sweeteners for obese people as an aid for weight reduction, according to the results of the present study. Expand
The Study on Long-Term Toxicity of D-Psicose in Rats
TLDR
No gross pathological findings were evident at dietary doses of 3% D-psicose or correlated with hypertrophy of liver and kidney, and no clinical chemical test value was suggestive of overt D-PSicose treatment-related toxicity. Expand
Dietary D-psicose reduced visceral fat mass in high-fat diet-induced obese rats.
TLDR
It is demonstrated that D-psicose produces a marked decrease, greater than erythritol, in weight gain and visceral fat in an established obesity model by inhibiting MSC differentiation to adipocyte, which can be useful in preventing and reducing obesity as a sugar substitute and food ingredient. Expand
d-Psicose increases energy expenditure and decreases body fat accumulation in rats fed a high-sucrose diet
TLDR
The anti-obesity effects of D-psicose could be induced not only by suppressing lipogenic enzyme activity but also by increasing EE in rats. Expand
D-psicose, a sweet monosaccharide, ameliorate hyperglycemia, and dyslipidemia in C57BL/6J db/db mice.
TLDR
The current findings suggest that D-psicose shows promise as an antidiabetic and may have antidyslipidemic effects in type 2 diabetes. Expand
Effects of Dietary D-Psicose on Diurnal Variation in Plasma Glucose and Insulin Concentrations of Rats
TLDR
It is suggested that supplemental D-psicose can lower plasma glucose levels and reduce body fat accumulation and might be useful in preventing postprandial hyperglycemia in diabetic patients. Expand
d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats
TLDR
It is suggested that d-psicose inhibits intestinal sucrase and maltase activities and suppresses the plasma glucose increase the normally occurs after sucrose and maltose ingestion, which may be useful in preventing postprandial hyperglycemia in diabetic patients when foods containing sucrose or maltose are ingested. Expand
Failure of d-psicose absorbed in the small intestine to metabolize into energy and its low large intestinal fermentability in humans.
TLDR
Low d-psicose fermentability was observed in intestinal bacteria and breath hydrogen gas tests, in which fructooligosaccharide was used as a positive control because its available energy is known to be 8.4 kJ/g. Expand
Rare sugar D-psicose improves insulin sensitivity and glucose tolerance in type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
TLDR
Data demonstrate that D-psicose controls blood glucose levels by reducing lipotoxicity in liver and by preserving pancreatic β-cell function, as well as protecting the pathological change of the β-cells of pancreatic islets. Expand
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