D-periodic distribution of collagen type IX along cartilage fibrils

  title={D-periodic distribution of collagen type IX along cartilage fibrils},
  author={Lloyd Vaughan and Markus Mendler and Stefan Huber and Peter Bruckner and Kaspar H. Winterhalter and Michael Irwin and Richard Mayne},
  journal={The Journal of Cell Biology},
  pages={991 - 997}
It has recently become apparent that collagen fibrils may be composed of more than one kind of macromolecule. To explore this possibility, we developed a procedure to purify fibril fragments from 17-d embryonic chicken sternal cartilage. The fibril population obtained shows, after negative staining, a uniformity in the banding pattern and diameter similar to the fibrils in situ. Pepsin digestion of this fibril preparation releases collagen types II, IX, and XI in the proportion of 8:1:1. Rotary… CONTINUE READING
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