D-methionine provides excellent protection from cisplatin ototoxicity in the rat.

@article{Campbell1996DmethioninePE,
  title={D-methionine provides excellent protection from cisplatin ototoxicity in the rat.},
  author={Kathleen C. Campbell and Leonard P Rybak and Robert P Meech and L. F. Hughes},
  journal={Hearing research},
  year={1996},
  volume={102 1-2},
  pages={90-8}
}
Cisplatin (CDDP) is a widely used chemotherapeutic agent. Unfortunately, CDDP is highly ototoxic. We tested D-methionine (D-Met), a sulfur containing compound, as an otoprotectant in male Wistar rats. Complete data sets were obtained for five groups of five animals each, including a treated control group (16 mg/kg CDDP), an untreated control group (administered an equivalent volume of saline) and three groups that received either 75, 150, or 300 mg/kg D-Met 30 min prior to the 16 mg/kg CDDP… CONTINUE READING
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