D-glucosamine-induced changes in nucleotide metabolism and growth of colon-carcinoma cells in culture.

@article{Krug1984DglucosamineinducedCI,
  title={D-glucosamine-induced changes in nucleotide metabolism and growth of colon-carcinoma cells in culture.},
  author={E. Krug and Alain Zweibaum and C Schulz-Holstege and Dietrich Keppler},
  journal={The Biochemical journal},
  year={1984},
  volume={217 3},
  pages={
          701-8
        }
}
Human colon-carcinoma cells were exposed to D-glucosamine at 2.5, 5 and 10 mM, concentrations that were growth-inhibitory but not cytocidal in the presence of a physiological glucose concentration. Labelling of these HT-29 cells with D-[14C]-glucosamine, followed by nucleotide analyses, demonstrated that UDP-N-acetyl-hexosamines represented the major intracellular nucleotide pool and the predominant metabolite of the amino sugar. D-[14C]Glucosamine was not a precursor of UDP-glucosamine. After… Expand
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