D-galactosamine lethality model: scope and limitations.

  title={D-galactosamine lethality model: scope and limitations.},
  author={Richard Silverstein},
  journal={Journal of endotoxin research},
  volume={10 3},
D-Galactosamine (D-galN) is well established as sensitizing mice and other animals to the lethal effects of TNF, specifically, and by several orders of magnitude. Protection by anti-TNF neutralizing antibody is complete, as is (metabolically-based) protection by uridine. Sensitization occurs regardless of the origin of the released TNF, whether it is released from macrophages and/or T-cells. The same is true for the challenging agent which leads to the release of TNF, whether it is endotoxin, a… CONTINUE READING

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