D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task.

@article{Schuster1992DcycloserineRT,
  title={D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task.},
  author={Guido M. Schuster and Werner J. Schmidt},
  journal={European journal of pharmacology},
  year={1992},
  volume={224 1},
  pages={
          97-8
        }
}
It is shown that D-cycloserine has cognition-enhancing properties in quinolinic acid hippocampal-lesioned rats. Lesioned rats had a severe impairment of working memory in an allocentric spatial reversal paradigm in the 8-arm maze, and performance could be restored with 12 mg/kg i.p. D-cycloserine, given 30 min before testing. The present findings favour the testing of D-cycloserine for clinical efficacy in patients with Alzheimer's disease with loss of pyramidal neurons and disconnected glycine… CONTINUE READING

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