D-beta-hydroxybutyrate extends lifespan in C. elegans

@article{Edwards2014DbetahydroxybutyrateEL,
  title={D-beta-hydroxybutyrate extends lifespan in C. elegans},
  author={Clare B. Edwards and John Canfield and Neil Copes and M. Rehan and David B Lipps and P. Bradshaw},
  journal={Aging (Albany NY)},
  year={2014},
  volume={6},
  pages={621 - 644}
}
The ketone body beta-hydroxybutyrate (βHB) is a histone deacetylase (HDAC) inhibitor and has been shown to be protective in many disease models, but its effects on aging are not well studied. Therefore we determined the effect of βHB supplementation on the lifespan of C. elegans nematodes. βHB supplementation extended mean lifespan by approximately 20%. RNAi knockdown of HDACs hda-2 or hda-3 also increased lifespan and further prevented βHB-mediated lifespan extension. βHB-mediated lifespan… Expand
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References

SHOWING 1-10 OF 106 REFERENCES
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
  • 302
  • PDF
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
  • 251
  • PDF
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
  • 761
  • Highly Influential
  • PDF
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
  • 497
  • PDF
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
  • 723
  • PDF
Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans
  • 688
  • PDF
...
1
2
3
4
5
...