D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.

@article{Cline1969DaminoAO,
  title={D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.},
  author={Martin J. Cline and Robert I. Lehrer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1969},
  volume={62 3},
  pages={756-63}
}
D-Amino acid oxidase has been identified within the granule fraction of human neutrophilic leukocytes. Leukocyte homogenates and purified kidney D-amino acid oxidase can utilize either isolated D-amino acids or some species of bacteria as substrates for the generation of hydrogen peroxide. When linked to leukocyte myeloperoxidase in vitro, purified D-amino acid oxidase constitutes a system lethal for certain bacteria. It is proposed that leukocyte D-amino acid oxidase and myeloperoxidase… CONTINUE READING

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