D-alanine in the frog skin peptide dermorphin is derived from L-alanine in the precursor.

@article{Richter1987DalanineIT,
  title={D-alanine in the frog skin peptide dermorphin is derived from L-alanine in the precursor.},
  author={Kirsten Richter and R J Egger and Guenther Kreil},
  journal={Science},
  year={1987},
  volume={238 4824},
  pages={200-2}
}
A D-alanine-containing peptide termed dermorphin, with potent opiate-like activity, has been isolated from skin of the frog Phyllomedusa sauvagei. Complementary DNA (cDNA) libraries were constructed from frog skin messenger RNA and screened with a mixture of oligonucleotides that contained the codons complementary to five amino acids of dermorphin. Clones were detected with inserts coding for different dermorphin precursors. The predicted amino acid sequences of these precursors contained… CONTINUE READING

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