D-Val22 containing human big endothelin-1 analog, [D-Val22]Big ET-1[16-38], inhibits the endothelin converting enzyme.

@article{Morita1994DVal22CH,
  title={D-Val22 containing human big endothelin-1 analog, [D-Val22]Big ET-1[16-38], inhibits the endothelin converting enzyme.},
  author={Akihito Morita and Motoyoshi Nomizu and M Okitsu and Kaeko Horie and Hidehiko Yokogoshi and Peter P. Roller},
  journal={FEBS letters},
  year={1994},
  volume={353 1},
  pages={84-8}
}
Endothelin converting enzyme (ECE) is essential for generation of the biological effects of endothelin-1 (ET-1) from a precursor, big endothelin-1 (Big ET-1). We synthesized four analogs of human Big ET-1[16-38], substituted with single D-amino acids at P1, P2, P1' and P2' positions. ECE activity was determined using an ET-1 specific radioimmunoassay system. None of the D-amino acid containing Big ET-1 analogs were apparently cleaved by ECE, however, one of the synthetic peptides, [D-Val22]Big… CONTINUE READING