D-Tagatose manufacture through bio-oxidation of galactitol derived from waste xylose mother liquor

@article{Feng2018DTagatoseMT,
  title={D-Tagatose manufacture through bio-oxidation of galactitol derived from waste xylose mother liquor},
  author={Sha Feng and Yucong Zheng and Jiao Chen and Kequan Chen and Fei Cao and Ming Yan and Pingkai Ouyang},
  journal={Green Chemistry},
  year={2018},
  volume={20},
  pages={2382-2391}
}
In this study, the bio-oxidation of galactitol to the valuable D-tagatose is presented. This proposed strategy could start with the refined by-product of waste xylose mother liquor formed by chemical hydrogenation. Through a computationally guided enzyme screening approach, a robust polyol dehydrogenase (PdPDH) was rapidly identified from a massive number of candidates. When coupled with a water-forming NADH oxidase (StNOX) for environmentally benign cofactor regeneration, subsequent reaction… 

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